Título del libro: Manganese: Chemical Properties, Medicinal Uses And Environmental Effects
Título del capítulo: Manganese inhalation induces alterations comparable to those found in Parkinson disease patients
MARIA ROSA DE LOURDES AVILA COSTA; VERONICA ANAYA MARTINEZ; RICARDO GARCIA RUIZ; JOSE DE JESUS ESPINOSA VILLANUEVA; PATRICIA ROSA ALEY MEDINA; JAVIER TADEO SANCHEZ BETANCOURT; ENRIQUE MONTIEL FLORES; LEONARDO REYNOSO ERAZO;
Autores externos:
Idioma:
Inglés
Año de publicación:
2012
Resumen:
Parkinson disease (PD) is characterized by diminished control over voluntary movement and progressive depletion of brain dopamine (DA) levels that stems from the large-scale loss of DA-producing neurons from the substantia nigra compacta (SNc). Despite the advances of modern therapy to treat the symptoms of PD, most of the patients will eventually experience debilitating disability. So, the need for neuroprotective strategies that will slow or stop the progression of the disease is clear. The progress in the understanding of the cause and pathogenesis of PD is providing clues for the development of disease-modifying strategies. In this regard, animal models of PD are essential for the preclinical evaluation and testing of candidate therapies. However, even when PD was one of the first neurological disorders to have aspects of the disease modeled in non-human animal species, there are inherent limitations such as intensive animal care after neurotoxins administration, spontaneous recovery, lack of bilateral characteristics of advanced PD, biochemical and ultrastructural nonspecific changes, but mainly the time course of the neurodegeneration in humans. Recently in our laboratory, we investigated the effects of divalent and trivalent manganese (MnCl2/Mn(OAc)3) mixture inhalation on mice to obtain a novel animal model of PD inducing bilateral and progressive cell death in the SNc. We found that after 5 months of inhalation, there was a decrease of 67.58% in the number of TH-immunopositive neurons and these alterations are correlated with evident deficit in the motor performance manifested as akinesia, postural instability and action tremor. More interesting is the fact that these alterations were reverted with L-DOPA treatment, suggesting that the motor alterations induced by the inhalation of the combination of manganese are related to nigrostriatal dopaminergic function, providing new light in the understanding of manganese neurotoxicity as a suitable PD experimental model. Nevertheless, there are many aspects to be evaluated in order to develop a more appropriated animal model for the study of this disease. In this chapter we provided evidence about neurochemical and ultrastructural changes observed in the striatum, Globus Pallidus and SNc of mice exposed to manganese mixture. We found si
Entidades citadas de la UNAM:
ISBN:
9781619429314
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Manganese inhalation induces alterations comparable to those found in Parkinson disease patients
Página inicial:
1
Página final:
26
Tipo de producto:
Capítulo de un Libro
