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Título del libro: Handbook Of Polycyclic Aromatic Hydrocarbons: Chemistry, Occurrence And Health Issues
Título del capítulo: PAH-DNA adducts in non-smoking inhabitants of Mexico City

Autores UNAM:
ALICIA HUERTA CHAGOYA; PAVEL PETROSYAN; JULIETA RUBIO LIGHTBOURN; MARIA EUGENIA GONSEBATT BONAPARTE;

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Autores externos:

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Idioma:
Inglés

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Año de publicación:
2013

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Resumen:

The Mexico City metropolitan area (MCMA) is one of the most densely populated cities in the world, with nearly 20 million inhabitants. One consequence of this urban concentration is the daily circulation of more than 4 million vehicles that generate elevated levels of polycyclic aromatic hydrocarbons (PAHs), which are not monitored or regulated. Several studies indicate that PAH levels in the MCMA ambient air are above those reported in other highly polluted cities, particularly during the winter season as a result of thermal inversions and the lack of rain. Exposure to PAHs can be ascertained by the determination of adducts on the DNA, which are lesions considered to be associated with an enhanced risk of cancer formation. Using a chemiluminescence immunoassay with an antiserum elicited against DNA modified with benzo[a]pyrene (B[a]P), we performed a monitoring study to determine the levels of PAH-DNA adducts during winter and the subsequent summer. The assay was performed on DNA isolated from peripheral blood lymphocytes from young non-smoking inhabitants of the MCMA. The levels of PAH-DNA adducts were higher in winter than in other times of the year, and were associated with airborne levels of particulate matter in the most highly affected areas. Our observations indicate the need for air quality standards and regulations for PAHs in the MCMA, as well as improvement of the strategies to reduce vehicle emissions. © 2013 Nova Science Publishers, Inc. All rights reserved.

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Entidades citadas de la UNAM:

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Fuente:


ISBN:
9781622574735
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
PAH-DNA adducts in non-smoking inhabitants of Mexico City
Página inicial:
369
Página final:
379

Tipo de producto:
Capítulo de un Libro