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Título del libro: Bt Resistance: Characterization And Strategies For Gm Crops Producing Bacillus Thuringiensis Toxins
Título del capítulo: Different models of the mode of action of Bt 3d-Cry toxins

Autores UNAM:
MARIA ALEJANDRA BRAVO DE LA PARRA; ISABEL GOMEZ GOMEZ; MARIO SOBERON CHAVEZ; GRETEL MENDOZA ALMANZA;
Autores externos:

Idioma:
Inglés
Año de publicación:
2015
Palabras clave:

BACILLUS-THURINGIENSIS TOXIN; PLANAR LIPID-BILAYERS; BRUSH-BORDER MEMBRANE; DROSOPHILA S2 CELLS; MANDUCA-SEXTA AMINOPEPTIDASE; CULTURED INSECT CELLS; CRY1AB TOXIN; DELTA-ENDOTOXIN; HELICOVERPA-ARMIGERA; HELIOTHIS-VIRESCENS


Resumen:

Bacillus thuringiensis (Bt) produces insecticidal proteins that are active against different insect orders. In particular, the family of the three domain-Cry toxins (3d- Cry) have important applications in controlling insect pests as spray products or in transgenic Bt plants. At least three different models account for the mode of action of these proteins. Two of them are based on the pore formation activity of the toxin and propose that larvae are killed by osmotic shock to their midgut cells. Differences in these models are related to the processes of receptor interactions and membrane insertion. The third model proposes that midgut cells are killed through a signal transduction mechanism that is triggered after the binding of 3d-Cry toxins to a cadherin receptor. In this chapter, we will review these models in light of the different resistance mechanisms to Cry toxins that have been documented so far in several insect species. © CAB International 2015. All rights reserved.


Entidades citadas de la UNAM: