Título del libro: Brenner's Encyclopedia Of Genetics: Second Edition
Título del capítulo: Rearrangements
RAFAEL RAUL PALACIOS DE LA LAMA;
Autores externos:
Idioma:
Inglés
Año de publicación:
2013
Palabras clave:
Amplicon; Amplification; Cancer; Deletion; DNA repair; DNA replication; Evolution; Genomic design; Homologous recombination; Inversion; Polymerase chain reaction; Replicon cointegration; Translocation
Resumen:
It is now universally acknowledged that genomes are dynamic structures, subjected to different types of rearrangements. This is due to the fact that rearrangements can be considered as a by-product of the cell's replication and repair mechanisms. In addition to transposition events, which are discussed elsewhere, genomic rearrangements produce different structural consequences including deletions, amplifications, inversions, and translocations of genetic material, and they can be recurrent or unique, as well as reversible or irreversible events. Their physiological consequences are extremely variable: including, but not limited to, allowing the cell to transiently cope with extreme changes in the environment, as is the case of some reversible amplification events; killing the cell by eliminating essential genetic material; causing genomic diseases; or inducing malignant cell transformation. In the genomic era, the availability of the complete nucleotide sequence of the genome of different organisms has made possible the prediction of certain recurrent rearrangements, which in turn has resulted in a novel type of genetic manipulation leading to the construction of alternative genomic architectures. Most important, genomic rearrangements are powerful evolutionary driving forces. © 2013 Elsevier Inc. All rights reserved.
Entidades citadas de la UNAM:
ISBN:
9780080961569
Editorial:
Elsevier Inc. Nombre de la publicación:
Rearrangements
Página inicial:
44
Página final:
46
