Título del libro: Endothelial Cell Plasticity In The Normal And Injured Central Nervous System
Título del capítulo: Early development of the vascular system supplying the brain
GABRIEL GUTIERREZ OSPINA;
Autores externos:
Idioma:
Inglés
Año de publicación:
2015
Resumen:
Vascular development in the embryonic and fetal central nervous system (CNS) is a highly stereotypical process that begins at the cervical levels of the neural tube (NT) and progresses towards the caudal and cephalic poles of the embryo following the process of neurulation. Until a few years ago, the ontogeny of blood vessels within the nervous system was believed to be a ?passive? process subordinated to the metabolic demands of the neural tissue (Park et al. 2003). An increasing body of evidence, however, shows that vascularization in the developing brain proceeds through a relatively autonomous process. The vascular network guarantees proper neuronal development by providing nutrients, migratory guidance and trophic modulatory factors that allow neural cells to proliferate and differentiate (Sun et al. 2010). Blood vessels also modulate synaptic plasticity (Hopper and Garthwaite 2006) and the interactions among neural, immune and endocrine cells during development (Matsumura and Kobayashi 2004). In addition, it is now widely recognized that the patterning of the brain?s vascular and neural networks is coordinated by the same set of molecular signals (Zacchigna et al. 2008). Early neurovascular communication thus establishes a life-long relationship between these systems that guarantees the proper function of the CNS. On the other hand, deficient neurovascular communication leads to several pathological conditions (Girouard and Iadecola 2006). © 2015 by Taylor & Francis Group, LLC.
Entidades citadas de la UNAM:
ISBN:
9781466599239
Editorial:
CRC Press Nombre de la publicación:
Early development of the vascular system supplying the brain
Página inicial:
1
Página final:
22
