Título del libro: Comprehensive Biotechnology, Second Edition
Título del capítulo: Secondary Metabolites
SERGIO SANCHEZ ESQUIVEL;
Autores externos:
Idioma:
Inglés
Año de publicación:
2011
Palabras clave:
Antibiotics; Anticancer agents; Antihelmintic agents; Beta-lactams; Hypocholesterolemic compounds; Idiolites; Immunosuppressants; Infectious disease; Microbial drugs; Secondary metabolites
Resumen:
Microbial secondary metabolites are low-molecular-mass products of secondary metabolism, usually produced during the late growth phase (idiophase) of microorganisms. They have unusual structures and their production arises from intracellular intermediates (amino acids, sugars, fatty acids, etc.), which are condensed into more complex structures by defined biochemical pathways. They are not essential for the growth of the producing cultures, but serve diverse survival functions in nature. They are very important for the human health and economics of our society. They include antibiotics, antitumor agents, cholesterol-lowering drugs, immunosuppressants, antihelmintic agents and other antiparasitics, herbicides, ruminant growth stimulators, agricultural fungicides, bio-insecticides, and others. The most important secondary metabolites have been the anti-infective drugs and, among these, the ß-lactams are the most important class. Other important classes include the aminoglycosides, tetracyclines, macrolides, lipopeptides, polyenes, and the echinocandins. Successful microbial secondary metabolites include many used to combat cancer, such as the anthracycline doxorubicin and bleomycin. Antitumor agents from plants that have been very useful are taxol and camptothecin. If modern medicine is to continue in its present form, novel families of antibiotics and other secondary metabolites must continue to be discovered and enter the marketplace at regular intervals. © 2011 Elsevier B.V. All rights reserved.
Entidades citadas de la UNAM:
ISBN:
9780080885049
Editorial:
Elsevier Inc. Nombre de la publicación:
Secondary Metabolites
Página inicial:
155
Página final:
167
