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Título del libro: The Comprehensive Sourcebook Of Bacterial Protein Toxins
Título del capítulo: Mechanism of action of Bacillus thuringiensis insecticidal toxins and their use in the control of insect pests

Autores UNAM:
MARIA ALEJANDRA BRAVO DE LA PARRA; JORGE FELIX SANCHEZ QUINTANA; GRETEL MENDOZA ALMANZA; ISABEL GOMEZ GOMEZ; SABINO PACHECO GUILLEN; BLANCA INES GARCIA GOMEZ; MARIO SOBERON CHAVEZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2015
Palabras clave:

WESTERN CORN-ROOTWORM; PORE-FORMING TOXIN; MODIFIED BT TOXINS; CRY1AB TOXIN; CRYSTAL-STRUCTURE; MANDUCA-SEXTA; SUBSP ISRAELENSIS; CRY11AA TOXIN; BINARY TOXIN; DOMAIN-II


Resumen:

Bacillus thuringiensis (Bt) bacteria synthesize different insecticidal proteins named Cry, Vip, and Cyt that are able to kill different insect orders, or nematodes. These proteins have been extensively used in insect control practices in agriculture as sprays or expressed in genetically modified plants. This chapter reviews the mechanism of action of these Bt proteins. In addition, genetic engineering has proven to help in developing novel biotechnological applications of these toxins, such as Cry1AMod toxins, which are active against insects that have developed resistance to Cry toxins; and zymogen-like Vip2 proteins, which can be used to control specific insect pests. Overall, the great diversity of Bt toxins represents a broad opportunity to control the most important insect pests that affect different crops, as well as vectors of human diseases such as malaria and dengue, and to design strategies to manage the development of insect resistance to Bt toxins. © 2015 Elsevier Ltd. All rights reserved.


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