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Título del libro: Nanoscale Fabrication, Optimization, Scale-Up And Biological Aspects Of Pharmaceutical Nanotechnology
Título del capítulo: The emulsification-diffusion method to obtain polymeric nanoparticles: Two decades of research

Autores UNAM:
ELIZABETH PIÑON SEGUNDO; VIRIDIANA GISELA LLERA ROJAS; GERARDO LEYVA GOMEZ; MARIA ZAIDA URBAN MORLAN; NESTOR MENDOZA MUÑOZ; DAVID QUINTANAR GUERRERO;
Autores externos:

Idioma:
Inglés
Año de publicación:
2017
Palabras clave:

Emulsification-diffusion method; Formation mechanism; Nanocapsules; Nanospheres; Polymeric nanoparticles; Protonanoparticles


Resumen:

Nowadays, several methods for preparing submicron particles from polymers are available. The emulsification-diffusion (E-D) method was proposed as an alternative to avoid the toxicity-solvent problems caused by the emulsification-evaporation; additionally, its simple implementation, high reproducibility and versatility have been confirmed for different research groups. This method is one of the first techniques analyzed from a mechanistic point of view and it has been used to encapsulate several kinds of drugs, including peptides and proteins. The objectives of this chapter are focused on the study of the pharmaceutical impact of the emulsification- diffusion method since it was introduced. We review and describe the critical preparative variables, constitutive materials, formation mechanisms and performance of the E-D method. The second part of the chapter includes an extensive collection of different types of drug-loaded nanoparticles obtained by this method. Finally, some novel innovations and applications of the method have also been compiled. © 2018 Elsevier Inc. All rights reserved.


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