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Título del libro: Aerobic Utilization Of Hydrocarbons, Oils, And Lipids
Título del capítulo: Membrane Lipid Degradation and Lipid Cycles in Microbes

Autores UNAM:
ISABEL MARIA LOPEZ LARA; OTTO GEIGER; FRANCISCO ROJO CALLEJAS;
Autores externos:

Idioma:

Año de publicación:
2019
Palabras clave:

OSMOREGULATED PERIPLASMIC GLUCANS; SINORHIZOBIUM-MELILOTI; ESCHERICHIA-COLI; OUTER-MEMBRANE; IDENTIFICATION; GENE; OLIGOSACCHARIDES; PHOSPHOLIPIDS; BIOSYNTHESIS; METABOLISM


Resumen:

All living cells are delimited from the exterior world by a membrane, and membrane-forming lipids are the structural determinants for membrane assembly and maintenance. Although biosynthesis of membrane-forming lipids is well understood in many organisms, turnover, degradation, and remodeling of these lipids are less studied. An initial degradation of glycerol-containing membrane lipids may occur by (phospho)lipases or transferases which remove distinct groups from the membrane lipid converting it into a lysolipid or diacylglycerol. These degradation intermediates can either be totally degraded into low-molecular-weight-metabolites or missing groups can be reintroduced onto the intermediates to convert them into fully functional membrane lipids again, thereby completing a lipid cycle. Classic examples in Escherichia coli are the lyso-phosphatidylethanolamine cycle, the diacylglycerol cycle, or cycles involving the isoprenoid undecaprenol. It is evident that many more lipid cycles exist in other proteobacteria and in grampositive bacteria and that these cycles play major roles in decorating biomolecules located outside the cytoplasmic compartment.


Entidades citadas de la UNAM: