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Título del libro: Proceedings Of The 2006 Ieee Symposium On Computational Intelligence In Bioinformatics And Computational Biology, Cibcb'06
Título del capítulo: Inferring functional coupling of proteins using the Evolutionary Bond Energy Algorithm

Autores UNAM:
JUAN ENRIQUE MORETT SANCHEZ;
Autores externos:

Idioma:

Año de publicación:
2006
Palabras clave:

Artificial intelligence; Bioinformatics; Genetic algorithms; Proteins; Bond energy algorithms; Cluster of orthologous groups; Functional relationship; Genetic search; Phylogenetic profile; Clustering algorithms


Resumen:

In this paper, we propose a new method for inferring functional relationships between proteins from their phylogenetic profiles. The Evolutionary Bond Energy Algorithm (EBEA) enhances the greedy BEA clustering algorithm with genetic search. We conducted a series of experiments using phylogenetic profiles provided by the Cluster of Orthologous Groups of Proteins (COG) database. Experimental results demonstrate that the proposed method is capable of inferring meaningful clusters of functionally related proteins. ©2006 IEEE.


Entidades citadas de la UNAM: