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Título del libro: The Innate Immune System In Health And Disease: From The Lab Bench Work To Its Clinical Implications: Volume 2
Título del capítulo: Modulation of the Innate Immune System by the Endocrine Disrupting Compounds Bisphenol A (BPA) and Phtalathes

Autores UNAM:
KAREN ELIZABETH NAVA CASTRO; MARGARITA ISABEL PALACIOS ARREOLA; VICTOR HUGO DEL RIO ARAIZA; MARIANA SEGOVIA MENDOZA; JORGE MORALES MONTOR;

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Autores externos:

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Idioma:

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Año de publicación:
2022

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Palabras clave:

Bisphenol A; dendritic cells; endocrine disruptors; innate immunity; macrophages; mast cells; microplastics; phthalates; pollution

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Resumen:

As a result of human socio-economic activity, industrial wastes have increased distressingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. A big health hazard is the sorption of toxicants to plastic while traveling through the environment. Two broad classes of plastic-related chemicals are of critical concern for human health?bisphenols and phthalates. Bisphenol A (BPA) is an endocrine-disruptor compound (EDC) with estrogenic activity. It is used in the production of materials that are used daily. The endocrine modulating activity of BPA and its effects on reproductive health has been widely studied. BPA also has effects on the immune system; however, they are poorly investigated and the available data are inconclusive. Phthalates are also EDCs used as plasticizers in a wide array of daily-use products. Since these compounds are not covalently bound to the plastic matrix, they easily leach out from it, leading to high human exposure. These compounds exert several cell effects through modulating different endocrine pathways, such as estrogen, androgen, PPAR? and AhR pathways. The exposure to both classes of plastic derivatives during critical periods of development has detrimental effects on human health. In this chapter, we have compiled the most important of their effects on the function of the innate immune system. © 2022 by Nova Science Publishers, Inc. All rights reserved.

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Entidades citadas de la UNAM:

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Fuente:


ISBN:
9781685076498
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Modulation of the Innate Immune System by the Endocrine Disrupting Compounds Bisphenol A (BPA) and Phtalathes
Página inicial:
271
Página final:
294

Tipo de producto:
Capítulo de un Libro