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Título del libro: Precision Medicine For Investigators, Practitioners And Providers
Título del capítulo: Role of respiratory proteomics in precision medicine

Autores UNAM:
LUIS MANUEL TERAN JUAREZ;
Autores externos:

Idioma:

Año de publicación:
2019
Palabras clave:

COPD; Idiopathic pulmonary fibrosis; Interface; Mass spectrometry; Respiratory diseases; Respiratory proteomics; SISCAPA; SWATH


Resumen:

Respiratory diseases are the third highest cause of deaths on the global scale, with the major burden switching from infectious diseases to chronic noninfectious disorders including asthma, chronic obstructive pulmonary disease, fibrotic lung disease, and lung cancer. Considering the complexity of the airways, for early diagnosis sophisticated technologies are necessary; initial symptoms are nonspecific, with frequently late clinical diagnosis. Mass spectrometry-based proteomics has rapidly advanced, and has permitted to gain a better understanding into disease mechanisms, to stratify diseases into their specific endotypes, and to identify novel therapeutic targets. We highlight potential biomarkers and their application to the clinic. © 2020 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: