®®®® SIIA Público

Título del libro: Eukaryome Impact On Human Intestine Homeostasis And Mucosal Immunology: Overview Of The First Eukaryome Congress At Institut Pasteur. Paris, October 16-18, 2019.
Título del capítulo: Role of Extracellular Traps Promoted by Intestinal Parasites. Relationship with Virulence

Autores UNAM:
ALFONSO OLIVOS GARCIA; MARIO NEQUIZ AVENDAÑO; JULIO CESAR CARRERO SANCHEZ;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Blastocystis spp.; Entamoeba dispar; Entamoeba histolytica; Giardia lamblia; Neutrophil extracellular traps (NETs); Pathogenicity/virulence; Reactive oxygen species (ROS)


Resumen:

NETosis is a form of programmed cell death in neutrophils characterized by the release of extracellular DNA traps (NET) composed of DNA associated with histones, granule enzymes and antimicrobial peptides. This mechanism of innate immunity has been linked to cell defense against different pathogens. In case of bacteria, NETosis has been directly associated with virulence, suggesting that its formation could depend on the pathogen?s ability to cause tissue damage. Moreover, NET formation can contribute to tissue destruction by promoting local inflammation and coagulation when exacerbated. © Springer Nature Switzerland AG 2020.


Entidades citadas de la UNAM: