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Título del libro: Immunotherapy In Resistant Cancer: From The Lab Bench Work To Its Clinical Perspectives
Título del capítulo: Cancer vs immune tolerance-The challenge of fighting ?self?

Autores UNAM:
MARGARITA ISABEL PALACIOS ARREOLA; KAREN ELIZABETH NAVA CASTRO;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Cancer; Immune; Immunotherapy; Mechanism; Tolerance


Resumen:

Immune tolerance is the state in which the immune system does not generate a response towards otherwise immunogenic antigens. Tolerance is crucial for life and its failures lead to autoimmune diseases. Tolerance may be achieved by preventing autoreactive clones from maturing, early in their development, or either eliminating or suppressing them if they reach periphery. However, there are moments when our own cells happen to be the disease, like with cancer. Herein, we describe the basic mechanism mediating those processes, namely clonal deletion, anergy induction, immunomodulatory cytokines, and regulatory cells. Finally, we comment on the immune recognition of cancer cells and why tolerance is a target for immunotherapy. © 2021 Elsevier Inc. All rights reserved.


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