®®®® SIIA Público

Título del libro: Immunotherapy In Resistant Cancer: From The Lab Bench Work To Its Clinical Perspectives
Título del capítulo: Environmental pollution as a risk factor to develop colorectal cancer: The role of endocrine-disrupting chemicals in the inflammatory process as a risk factor to develop colorectal cancer

Autores UNAM:
KAREN ELIZABETH NAVA CASTRO; JORGE MORALES MONTOR;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Colorectal cancer; Endocrine-disrupting chemicals; Environmental pollution; Immune resistance; Therapeutics


Resumen:

Environmental pollution is nowadays the first risk factor associated with the development of lung cancer, stroke, and heart disease. Within the universe of the complex mix of pollutants that shape the environment, the importance of endocrine-disrupting compounds (EDCs), such as bisphenols, phthalates, polycyclic aromatic hydrocarbons (PAHs), and pesticides, has been highlighted in recent years because of our chronic and ubiquitous exposition, particularly by ingestion of food and water, and their interference in hormone and immune functions. EDCs are associated principally with breast cancer development, but there is a poor understanding of the relationship with other neoplasms such as colorectal cancer (CRC). The objective of this chapter is to address the potential carcinogenic role of EDCs in the development of CRC, focusing on inflammation and neuroendocrine-immune regulation. First, we will describe the interaction between inflammatory bowel disease and CRC in terms of disruption of intestinal permeability, dysbiosis, and immune response induced by EDCs. Moreover, we delve into the neuroendocrine axes involved in the progression of this pathology. © 2021 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: