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Título del libro: Understanding Sexual Dimorphism
Título del capítulo: Sexual dimorphism in ulcerative colitis-associated cancer

Autores UNAM:
JORGE GUSTAVO MORALES MONTOR;

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Autores externos:

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Idioma:

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Año de publicación:
2023

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Palabras clave:

Colorectal cancer; Dihydrotestosterone; Estradiol; Immunendocrine interaction; Sex steroids; Sexual dimorphism; Testosterone; Ulcerative colitis

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Resumen:

Sexual dimorphism (SD) is the difference in morphology and physiology between sexes of the same species; in diseases, SD can reflect the susceptibility associated with gender in humans. In colorectal cancer, men have a higher incidence than women, independently between ethnicity or geographical location, suggesting that sex steroids are involved in the development of colorectal cancer (CCR). One of the principal factors that is involved in the development of CCR is the chronic inflammation of inflammatory bowel diseases, principally ulcerative colitis, which also has a greater incidence of men. The relationship of sexual dimorphism in colitis-associated cancer and the role of sex steroids is poorly understood, however, some research has begun to elucidate the mechanisms that underlying the effect of these molecules through the use of animal models. First, males develop more tumors and high grade of inflammation than females and pathways such as NF-kb, NFR-2 and NLRP3 that are closely related with inflammation are involved in this process. Estradiol protects both males and females from the development of colon tumors. Although most studies focus on the effect of estrogens, some research has begun to investigate the role of androgens. Both T4 and DHT stimulate the growth of colon neoplasia in both sexes. Besides, regulate the segregation of proinflamatory cytokines related with NF-kb, NFR-2 and NLRP3. However, there is not a complete characterization of immune cells and soluble factors in the tumor microenvironment. For example, it would be interesting to analyze the infiltration of cells with an anti-inflammatory phenotype, which, it is well known, inhibits the elimination of tumor cells. © 2023 Nova Science Publishers, Inc.

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Entidades citadas de la UNAM:

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Fuente:


ISBN:
9798886979459
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Sexual dimorphism in ulcerative colitis-associated cancer
Página inicial:
209
Página final:
235

Tipo de producto:
Capítulo de un Libro