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Título del libro: Pharmacoresistance In Epilepsy: From Genes And Molecules To Promising Therapies, Second Edition
Título del capítulo: Cellular and Molecular Mechanisms of Neuroinflammation in Drug-Resistant Epilepsy

Autores UNAM:
OCTAVIO FABIAN MERCADO GOMEZ; VIRGINIA SELENE ARRIAGA AVILA; ANGELICA VEGA GARCIA; DIANA YURIDIA ORGANISTA JUAREZ; MARA ALAIDE GUZMAN RUIZ; ROSALINDA GUEVARA GUZMAN;
Autores externos:

Idioma:

Año de publicación:
2023
Palabras clave:

Adaptive immune system; Blood-brain barrier; Drug-resistant epilepsy; Innate immune system; Oxidative stress


Resumen:

Drug-resistant epilepsy (DRE) is characterized by the persistence of epileptic seizures despite the administration of antiepileptic treatments. The pathogenesis of this condition has been associated with many different molecular and cellular mechanisms. In this chapter, we describe how the CNS immune response is associated with the onset of epilepsy and the molecular mechanisms underlying brain injury associated with neuroinflammatory response triggered by epileptic seizures. Next, we describe the possible role of neuroinflammation in the progression from epilepsy to DRE. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2013, 2023.


Entidades citadas de la UNAM: