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SISTEMA INTEGRAL DE INFORMACIÓN ACADÉMICA - PÚBLICO
Título del libro: Technical Proceedings Of The 2012 Nsti Nanotechnology Conference And Expo, Nsti-Nanotech 2012 Título del capítulo: Copper complexes loaded on nanostructured TiO 2 materials as citotoxic agents of cancer cells
Copper complexes (CC) were loaded on a functionalized titania with the purpose to determine their anticancer properties. Each CC was incorporated to titania during the hydrolysis step of the titanium butoxide precursor using the sol-gel procedure. The cytotoxic properties of both CC alone as well as those loaded on titania were determined using the RG2 rat glioblastoma cell line. We used UV-VIS and FTIR spectroscopy, and N 2 adsorption-desorption technique for the sample characterization. An "in vitro" release test was developed as well. The spectroscopy studies indicate that CC did not undergo any structural change during the synthesis procedure. The textural properties of titania were affected by the incorporation of the CC molecules. The classical first order kinetics were observed from the release profiles. A substantial death of RG2 cell was observed when they were treated with low concentrations of CC alone and Cu-TiO 2 materials compared with Cis-Pt, TiO 2 and RG2 non treated cell.